NEUR 3403 Lecture Notes - Lecture 6: Interleukin 10, Interleukin 4, Dysthymia
4 Sep 2016
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Growth factors support the survival, growth, and proliferation of cells. Acute stress reduces bdnf in the limbic system, particularly the hippocampus. Controllable and uncontrollable stressors reduce bdnf mrna in dentate gyrus of hippocampus (bland et al. , 2007) Reductions persist if stressor is unpredictable (gr nli et al. , 2006) Exercise increases levels of bdnf, which maintains and regenerates adult nerve cells. Inescapable stress slightly increases bdnf, whereas escapable stress greatly increases. Fgf-2 and bdnf in the mpfc and hf are differentially regulated by controllable and uncontrollable stressors . Fgf-2 is more responsive to behavioral control of a stressor than is bdnf . Early life experiences may have long-lasting effects on bdnf. Different epigenetic status of gdnf in stress-reactive vs. stress-resilient mice. Stressors cause multiple neurochemical and growth factor changes. Changes in neurotransmitters and growth factors reflect adaptation to demands of stressor. Macrophages: breakdown of foreign and dead cells, presentation of antigens to lymphocytes, meningeal, perivascular, choroid plexus.
