NEUR 3401 Lecture Notes - Lecture 11: Basal Rate, Paraquat, Rotenone
21 Feb 2020
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Feb11,2020 you have to inject it doesn"t pass bbb cell death is quick if youinject it in snc or mfb. Biphasic tf injected into str not progressive no lewy body. Shows pathologicalturning behaviour when challenged w a da agent ex amphetamine motor coordination deficit notremors higher density. Snn have a higher basal rate of oxidative phosphorylation have more complex axons already at max energetic nis hard to cope w further challenges higher density of microglia high nt of fe higher axonal arborization collateral. Rotenone organic still not safe f cause some degeneration of snc mutations of dat snips make you more vulnerable might be the first hit. Paraquat pq inecticide derived from south america roots can induce l synuclein inclusions lewy like bodies complex 1 mt like mptp inhibitors inhibit atp production links to pd have been found in herbicide synthetic.
