NEUR 3401 Lecture Notes - Lecture 6: Myeloid Tissue, Human Microbiota, Phagocytosis
31 Jan 2020
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Protects from pathogens like parasites bacteria also looks for dead dying or mutated cells. 1st physical chemical defences skin etc foreign molecules virus membranes normal flora. T cells white blood cells leukocytes made in bone marrow bone marrow makes exeption microglia all immune cells. Bi directional communication immune system communicate it is how the brain w one another how cytokine signal. Receptors on immune cells neurotrans neuropeptides neurohormones ex dak on. Il io do the opp bring the brain to homeostasis cytokines are 15 messengersthat influence brain can induce fever behavioural deficits apa activity brain monoamine turnover verypotent can come in the brain via special transporters. Interferon ifn atypeofcytokine interfere w viral can have anti of hepatitis makes them depressed tho replication tumor effects as treatment listen to this partagain. And these pattern recognition receptors lex tlrs pathogens have certain motifs patterns these recognize those patterns. Tlr 3 recognizespoly i c viral motifs cytoplasm.
