NEUR 3207 Lecture Notes - Lecture 2: Reticular Formation, Raphe Nuclei, Light Sleeper

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Lecture #2 modulatory systems of the brain. They act all over the brain and modulate vast assemblies of post synaptic neurons (ptsn) by having lots of collaterals (i. e. branching) Changes the way of how the neuron will respond to an input. Involved in the regulation of attention, arousal, sleep-wake cycle, learning and memory, anxiety, pain, mood, brain metabolism. It does not directly stimulate or inhibit it just enhances the effects of other afferent projections to the same ptst. It seems like ne speeds up the rate of information processing. Opening the temporal and spatial window (remember temporal and spatial summation) Neurons in the lc are very responsive to new unexpected, nonpainful sensory stimuli in the environment (they are brief, phasic responses: progressively decreases w/ loss of attention, less activity under conditions of low stimulation. Most active during periods of wakefulness, arousal and active states.

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