NEUR 3204 Lecture Notes - Lecture 8: Cyclic Adenosine Monophosphate, Hash Oil, 5-Ht2C Receptor

• School: Carleton University
• Department: Neuroscience
• Course: NEUR 3204
• Professor: Patrice Smith

Document Summary

Large-leaf tobacco (nicotiana tabacum) and small-lead tobacco (nicotiana rustica) Nicotine is an alkaloid found in tobacco leaves. A typical cigarette contains 6 to 11 mg of nicotine, though no more than 1 to 3 mg actually reaches the smoker s bloodstream: bioavailability. Most nicotine is metabolized to cotinine by the liver enzyme cytochrome p450: cotinine not as potent but can bind to receptors, nicotine cytp450 cotinine. Nicotine enters the smoker s lungs on tiny particles called tar, that is known to be carcinogenic. Tar contributes to the taste and smell of cigarette smoke, and along with nicotine, these sensory qualities contribute to the reinforcing effects of smoking. Nicotine readily passes through the surface of the lungs and into the bloodstream. It is absorbed to a lesser extent through the mouth and nostrils when tobacco is chewed or snorted as snuff. Elimination half-life of nicotine is around 2 hours.