NEUR 3204 Lecture Notes - Lecture 5: Ligand-Gated Ion Channel, Nice Ltd., Catecholamine

• School: Carleton University
• Department: Neuroscience
• Course: NEUR 3204
• Professor: Matthew Holahan

Document Summary

Alternativesplicing yougetsplicingvariants whichproduces diff formsof a proteinfrom the same gene highlyregulated. Aa properties proteins membrane bound hydrophobic across membrane in contact w membrane lipophilic non polar hydrophilic in extra intra cellularsides tend to attractotherprotein. Ionotropic hydrophilicwill linethepore polar wook noooo hydrophobic are found in the center ofthemolecule stabilizesstructure nonpolar hydrophilic are found on thesurface b ctheycan interact w h2o water soluble polar. 30 structure mostproteins take up a globular structure w hydrophobic core surrounded by a hydrophilic outer layers creb notionotropic enzyme. 40 structure protein subunits will interact to form a larger aggregateprotein complex ex machr has 5subunits you can haveheterodimers or homodimers the subunits can move in and out lthehave weak bonds. A diversity offthof that protein of thesemodificationsphosphorylation excreb. Reversiblethatregulatesproteinfh_ on or off what does creb look like lecture5 dopamine hmmm. Tyrosine is an essential aa from ur diet premovescoz affopmeopa dnf transporter. Tty th thhididermoextyefamsngdspopa ofth tyrosinehydroxylaseis the rate limitingagentenzyme doesn"tcross bbb soyoucan"tjustgivesomeone goesintovesiclevia vesicularmonoamine.