NEUR 2202 Lecture 3: Chapter 3 (reading) - Feb 7, 2019
25 Feb 2019
School
Department
Course
Professor
3Ithe
samegenemayplayarole in manydifferent developmentalevents
Pleiotropy ageneinfluencesmanydifferenttraitsespeciallywhentheyseemunrelated
ex Shh plays arole in development of floor platedifferentiation of motor neurons splittingthe
opticplate to make 2opticcups
redundancy severalgenes allcontribute to make asingletrait
exNoggin Chord
in Follistatinall work together for neuralplatedifferentiation
3.2 the developing brain generatesneurons at atremendousrate
mitoticfigures acell thats in themiddleofmitosis
alwaysseen in tissues thatwere knownto be growing
neurogenesis mitosis ofcellsthat will giverise to neurons gliogenesis same but glia
peal
surface
Bsymmetricdivision cAsymmetricaldivision
is aD
Hq 1s
phase
1µg yµ
PMitotic ventricle
EE.EE pnase es
iaEemf.phase Neural
tube
fmarginal
ventricularzone where
cell
division
occurs zone
Marginal
cone outermost
layer
thatlater
becomes
cerebral
cortex I'zntoneremediate
Iventricular
zone
33Shortlyafter divisionneural cells diverge to become neurons or glia
glialfibrillary acid protein
CGF
AP protein seen in radialglial astrocytes but not neurons
neuroblasts gli
oblasts are athing
CelltypeProcestern
Selfrenewal Q
i
Progenitor
Progenitor produced if
pya eu jy.z
IX
neural glial
t1
Neurons glia au
types astrocytes
specialized differentiate of
neurons oligodendrocytes
34Cerebellum cerebralcortexform inlayers
Purkinje cells singlelayer wgranulearound it
internalgranulelayer on
topofintermediate zone
externalgranulelayer on
topof marginal zone
Sob
ventricular zone SVZ on topofventricular zone cells can divide here and it may be a
region where new neurons grow in adulthood
byadulthood ventricular zone shrinks 9forms the ependymal layer linescerbralventricles
Whitematter axons inside
graymatter madefromcorticalplatecellbodies
molecularlayeroutermostlayer of cerebral cortex
neocortex btwmolecular layer marginalzone
Document Summary
3 i thesamegenemayplay a role in manydifferent developmentalevents. Pleiotropy a geneinfluencesmanydifferenttraitsespeciallywhentheyseemunrelated ex shh plays a role in development of floor platedifferentiation of motor neurons splittingthe opticplate to make 2 opticcups redundancy severalgenes allcontribute to make a singletrait exnoggin chordin follistatinall work together for neuralplate differentiation. 3. 2 the developing brain generatesneurons at a tremendousrate mitoticfigures a cell thats in themiddleofmitosis alwaysseen in tissues thatwere known to be growing neurogenesis mitosis ofcellsthat will give rise to neurons gliogenesis same but glia. Ee. ee a sphase1 g esiaeemf. phase y p mitotic ventricularzone wherecelldivisionoccurs. 33 shortlyafter divisionneural cells diverge to become neurons or glia glialfibrillary acid proteincgfap protein seen in radialglial astrocytes but not neurons neuroblasts glioblasts are a thing. Purkinje cells singlelayer w granulearound it internalgranulelayer ontopofintermediate zone externalgranulelayer ontopof marginal zone on topofventricular zone cells can divide here and it may be a. Sobventricular zone svz region where new neurons grow in adulthood byadulthood ventricular zone shrinks 9forms the ependymal layer linescerbralventricles.
