NEUR 2201 Lecture Notes - Lecture 17: Mechanotransduction, Threshold Of Pain, Muscle Spindle
2 Jan 2019
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Note: you need to know if a pathway is gs, gi, g0 or a gq pathway. Review of the pathway to trp channel opening. The g-protein enhances the response to tpr agonists (i. e. trp sensitization) The net result is that trp channels can amplify that effects of gpcrs and mediate their contributions to transmission of pain, itch, couch and neurogenic inflammation. Inflammation and pain changes in transcription and translation of trp channels and other proteins can switch the chemical phenotype of the neurons from their state in na ve condition to an altered state during inflammation. The net effect of these changes is peripheral sensitization; that is, a reduction in the pain threshold at the site of inflamed tissues. Auditory system: mechanotransduction, k+ as the key mediator, ca++ signaling and neurotransmitter release, frequency coding. Somatosensory system: types of receptors, fast vs slow adapting, neural innervation of muscle spindle, mechanoreceptor mechanism of proprioception. Nociception: two types of receptors: gpcr and trp.
