NEUR 1203 Lecture Notes - Lecture 5: Traumatic Brain Injury, Blast Injury, Penetrating Trauma

• School: Carleton University
• Department: Neuroscience
• Course: NEUR 1203
• Professor: Ashley Thompson

Document Summary

Neuron depolarization and firing: too much ca2+ inside cells is bad. It ends up sequestered in the mitochondria: this disrupts the production of atp , which can lead to apoptosis , 2) energy crisis. Immune activation the basics: excitotoxicity glu, k+/ca2, energy crisis - glucose/ o2. Just like our bodies, our brain has an immune response when things are not going well : certain sites of the human body have immune privilege (e. g. testes, placenta, eyes) Introduce a foreign substance and it will not cause an inflammatory response: brain used to be thought of as immune privileged, active interaction with the peripheral immune system, not truly privileged, but still pretty darn protected. Immune system basics: the immune system is decentralized. In 2011, at age 50, dave shot himself in the chest he left a note asking that his brain be studied (cte was diagnosed post-mortem: detection/diagnosis, symptom inventory.