CHEM 1004 Lecture Notes - Lecture 1: Therapeutic Index, Estrone, Celecoxib

• School: Carleton University
• Department: Chemistry
• Course: CHEM 1004
• Professor: Gerald Buchanan

Document Summary

Course outline chem 1004 *** (approximate times allotted! approximate number of pp slides! Week 1a (3 hours: 81 ppt slides) (a) drugs and the human body (55 slides) Introduction to drug naming, chemical structures, dosages, therapeutic indices, units (b) organic chemistry overview (40 ppt ) Topics: bonding at c, structures, simple naming, isomers, and functional groups: halocarbons, alcohols, amines, aldehydes, ketones, carboxylic acids, esters, and amides. More complex structures: acetaminophen, ibuprofen, steroids (cholesterol) estrone and estradiol. Text references: liska chapters 1 and 2; appendix a. 3. Week 1b (a) what happens to drugs after we take them? (84 ppt) Topics: routes of administration, formulation, how drugs get to their targets, biological membranes, blood-brain barrier, drug metabolism, effective dosages, therapeutic index, drug-drug and drug-food interactions. Text reference: chapter 4 liska (b) non-steroidal anti-inflammatory drugs (nsaids) (52ppt) Week 2a (a) drugs at the synapse (47ppt) Structure and composition of the synapse, neurotransmitters: acetyl choline, norepinephrine, dopamine, serotonin,