BIOL 2303 Lecture Notes - Lecture 15: Novobiocin, Cyclic Adenosine Monophosphate, Sodium Chloride
2 Nov 2020
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What changes: the growth increases at 8 hours because the levels of glucose decrease which cause the camp to bind to cbp and all of this stimulates the transcription of the lac gene. This produces b- galactosidase which breaks down lactose. The 2 regulators themselves must respond to different signals, which enables both to control the operon differently. Often, environmental change is detected by a sensor protein, which then transmits information to the regulatory machinery- this is signal transduction. Kinase: phosphorylates other proteins or self (auto-phosphorylation) Sensor kinase: auto-phosphorylates at a specific histidine residue. Phosphate is then transferred to the response regulator. Phosphorylation activates the response regulator, which then binds dna, leasing the positive or negative regulation. Quorum sensing: response to population density: many traits are density dependent, virulence factor production (e. coli o157:h7, luminescence (v. fischeri, bioflim formation (p. aeruginosa) Quorum sensing depends on one or more signal transduction mechanisms.
