BIOL 2107 Lecture Notes - Lecture 7: Replica Plating, Mutagen, Gamete

• School: Carleton University
• Department: Biology
• Course: BIOL 2107
• Professor: Bahram Samanfar

Document Summary

Mutation are the heritable changed in dna base sequences. Dna mutation is wrong because mutation always happens in dna: forward mutations wt allele to diff allele, reverse mutation mutant allele back to wt. Inversion: the sequence gets flipped and turned: because dna sequence has polarity. Reciprocal translocation: sequence of chromosome 1 is move to chromosome 2. Important factors: different gene size, susceptibility of [articular genes to various mutagenic mechanisms. Eukaryotes have a higher rate than prokaryotes, duh : many cell divisions take place b/c zygotes formation and meiosis in germ cells, more chance to accumulate mutations. Diploid organisms tolerate more mutations because the other one will compensate. Experiment: examined origin of bacterial resistance to phage infection (fluctuation test) Most cells died but a few can grow and divide. This means that those cells are resistant, and. Infected wt bacteria with phage this makes them different: the differences are so minimal that you can"t see them in the phenotype.