BIOL 1104 Lecture Notes - Lecture 16: Chi-Squared Test, Neurodegeneration, Genotype Frequency

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When applying the hw principle, we compare the reality (observations) to the. Lecture 16 theoretical expectation, use this chart : We first used the observed genotype frequencies (or counts) to calculate the observed allele frequencies for the otter population. We then used the observed allele frequencies to calculate the expected genotype frequencies using the hw equation. We then tested if the observed genotype frequencies differ significantly from the expected genotype frequencies using a chi square test. Kuru is a neurodegenerative disease similar to creutzfeldt jakob disease. Kuru killed >1% of the fore population in the 1950"s and 60"s. It was contracted by eating the brain of infected people during ritualistic mortuary feasts (that"s right!) Prp gene influences the vulnerability to prion diseases such as creutzfeldt-jakob disease. Met and val are two common alleles for the prp gene. Genotypes of elder women having participated in mortuary feasts that did not contract kuru:

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