KINE 2P97 Lecture Notes - Lecture 9: Exercise Intensity, Calorimetry, Biopsy
8 May 2018
School
Department
Course
Professor
KINE 2P97
Muscle Physiology & Exercise Metabolism
Human Skeletal Muscle Biopsies
Energy System Partitioning & Exercise
- If power output is very high, then the oxidative processes are too slow to be of much
use
- Therefore, most of the energy provided is by PCr and glycolysis
- PCr ad glyolysis do’t ake ery uh ATP o their o ut they ake it FAST
- These pathways must increase their activity 100-200x to meet demand in intense
exercise
- Regenerating the ATP which is used in contraction
Indirect Calorimetry
- Volume of air going into the body, then inspired
- Then measure the expired air
- And then calculate the VO2 Max
Maximal Oxygen Consumption (VO2 max)
- VO2 Max: is the maximal rate of oxygen uptake during maximal exercise, reflects the
capacity of the heart, lungs, and blood to deliver oxygen during a dynamic exercise
- In simpler terms, the maximal amount of air your body can take in, the amount of
oxygen the muscles can use and the rest of the air left over from intake
- Considered to be most valid measure of the functional capacity of the cardio-respiratory
system
- Central HR X SV capacity of heart, lungs, and blood to transport oxygen to working
muscles
- Peripheral a-vO2diff ability of muscles to utilize oxygen during exercise
VO2 max vs VO2
- Measure capacity for aerobic performance
- Maximal ability to generate ATP aerobically
o Maximal activities of aerobic enzymes in the mito.
o Maximal rate of delivery of NADH and FADH2 to ETC
- Maximal ability to delivery O2
o Ability of cardiovascular system to increase blood flow
o Ability to deliver O2 from lungs blood, blood mito
Estimating Fuel Utilization with RER
- During exercise, the RER is usually between 0.7 and 1.0
- Limitations:
o Whole body estimate of fuel utilization
o Only applicable during steady-state exercise
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