KINE 2P97 Lecture Notes - Lecture 8: Amine, Alpha-Ketoglutaric Acid, Pyruvic Acid
8 May 2018
School
Department
Course
Professor
KINE 2P97
Muscle Physiology & Exercise Metabolism
Beta-oxidation: FFA breakdown
- FFA chains are broken down to generate Acetyl-CoA
- Occurs in mitochondrial matrix
- Acetyl-CoA enters TCA
Fatty Acyl Coa structure
- Can be as long as 28 carbons
***know the products of beta-oxidation
Each turn of the cycle
- Removes 2 carbons from the FFA chain
- Produces; 1 Acetyl CoA, 1 NADH, 1 FADH2
- Process repeats until the FACoA has been broken into 2 Acetyl CoA molecules
Energy production
- Acetyl coa
o Enters TCA cycle, produces: 1 ATP, 3NADH and 1FADH2
- NADH
o To ETC, produces: 3 ATP
- FADH2
o To ETC, produces: 1 ATP
***If you have a given substrate, what is the final outcome in terms of ATP production
Regulation
- Controlled by mass action
- Rate is determined by the availability of FACoA in mitochondria (CPT I)
- Accomplished upstream
o ATGL
o HSL
o FAT/CD36
o CPT I
find more resources at oneclass.com
find more resources at oneclass.com
Document Summary
Ffa chains are broken down to generate acetyl-coa. Can be as long as 28 carbons. Removes 2 carbons from the ffa chain. Produces; 1 acetyl coa, 1 nadh, 1 fadh2. Process repeats until the facoa has been broken into 2 acetyl coa molecules. Acetyl coa: enters tca cycle, produces: 1 atp, 3nadh and 1fadh2. Nadh: to etc, produces: 3 atp. Fadh2: to etc, produces: 1 atp. ***if you have a given substrate, what is the final outcome in terms of atp production. Rate is determined by the availability of facoa in mitochondria (cpt i) Accomplished upstream: atgl, hsl, fat/cd36, cpt i. No storage place for protein as fuel source. Must break down protein into amino acids. Nitrogen cannot provide energy: must be removed so the remaining carbon skeleton can be metabolized. Removal of nitrogen from the amino acid molecule (in liver) Via deamination n is removed from protein and expelled from the body as urea (in urine)
