KINE 2P84 Lecture Notes - Lecture 2: Bone Resorption, Bone Mineral, Collagen

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Growth and development: bone tissue and skeletal growth: looking at the development of bone as a tissue bones determine our height (98%) other 2% is cartilage why taller in morning (cartilage compresses, can change up to 2cm) Minerals and cells create calcium and phosphate. Adult skeletal mass 30% mineral 35% calcium. Osteoclasts regulation of the flow of minerals and nutrients (part of communication between cells) Long bones change shape by increasing in width/length. Bone is a very dynamic tissue (always changing) 5% of bone tissue is turned over each year (old but new in) (adults) Old: resorption < resorption leads to osteoporosis (holes/pores in the bone) (loss of bone tissue) Osteoporosis is set in childhood, only way to prevent is have higher formation than resorption (in childhood), more we do lower risk is. Endochondral replacement of cartilage by bone ex: long bones. Mesenchymal cells (embryonic) lime buds (differentiation) cartilage cells. Longitudinal growth epiphysis (occurs at = end of long bones)

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