HLSC 3P97 Lecture Notes - Lecture 8: Tnf Inhibitor, Rheumatoid Arthritis, Silicosis
2 Apr 2018
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Document Summary
Treatment with tumor necrosis factor alpha (tnf-alpha) blocker. Tnf-alpha is an important mediator in helping to manage tb. When someone is taking a tnf blocker (as someone would with a disease like crohn"s) Releases tb from the granuloma in the lung - de-contains them. Given tnf blockers, because it was approved, however once started being given to the patients, they started coming back with active tb. Tb to alveolus --> alveolar macrophage-->interstitium --> dendritic cell --> lymph node --> adaptive immune response --> lung inflammation/granuloma development. Allows tb in because they eat for a living, but tb deacidifies the phagolysosome, allowing it to proliferate. Antibodies do not protect against tb, but it will make them anyway. Dendritic cell carrying the antigen, has activated the t cells. Small vessels being bullied, meaning that no more cytokines can be produced, and the cytoskeleton will collapse. Will result in necrosis, and loss of lung function.
