HLSC 3P97 Lecture Notes - Lecture 11: Minimum Inhibitory Concentration, Protozoa, Keratin
15 Dec 2017
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Drug also has low infinity for keratin in the nail, infection in skin not nail. The lower the mic, the higher the drug potency. Mic very potent = no growth (least dilute) Like hiv, hcv needs to bind first to the cell surface in order to get into cell. Once it binds to the surface, it fuses and un-coats and released +ve rna strand and copies (translates) into its protein, when protein is translated, it clips protein and forces cell (transcription. Rna to produces more rna), clips huge poly protein and assembles and exports the cell. Unlike hiv, hcv does not enter the genome. Non-structural proteins are viral proteins required for assemble, budding and rna replication. Uses its own polymerase to elongate rna. 75% of our society will be infected with genotype 1 (wild type) (aka mother quasispecies (kids) complicates therapy. Only 20% of patients who took treatment were cured.
