HLSC 3P19 Lecture Notes - Lecture 4: Membrane Transport Protein, Neurotransmitter Transporter, Competitive Inhibition
15 Dec 2019
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Document Summary
Therapeutic effects of drugs result from their interaction with molecules in the patient. Most drugs interact with these specific macromolecules altering their biochemical or biophysical activity. Receptor conceived as component of a cell. Consequences of the existence of receptors: they determine the quantitative relations between dose or concentration of drug and pharmacologic effects, receptors are responsible for selectivity of drug action, receptors mediate the actions of pharmacologic agonists and antagonists. Most receptors for clinically relevant drugs or neurotransmitters (ligands) are proteins. In certain cases, some agents (ligands) act directly on dna or membrane lipids. Receptors historically have been discovered after the drugs that bind them. Advances in molecular biology and genomic sequencing and the prediction of structural homology to other previously known receptors. Many drugs can bind to a greater diversity of receptors than previously anticipated. The best characterized receptors are regulatory protein: mediate endogenous chemical signals . These receptors mediate some of the most useful therapeutic agents.
