HLSC 3P19 Lecture Notes - Lecture 6: Allergic Rhinitis, Vascular Smooth Muscle, Adenylyl Cyclase
15 Dec 2019
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Document Summary
Produced as a response to exposure to foreign proteins: some examples include: pollens, or cockroach, dust mites, animal dander, and others that stimulate the production of ige in people who have exposure to them. Asthma clusters with other allergic diseases in family groups: allergic rhinitis, eczema, food allergy. Ige binds to high affinity receptors (fcer1) on mast cells in the airway mucosa. Re-exposure to the allergen triggers the release of mediators stored in the mast"s cell granules and the synthesis and release of other mediators. These mediators once released cause a contraction of the smooth muscle and the vascular leakage responsible for the acute bronchoconstriction of the early asthmatic release. The main mediators are: histamine, tryptase, leukotrienes c4, d4, prostaglandin d2. The response is often followed by another phase. In 3 to 6 hours, there is a second most sustained phase of bronchoconstriction late asthmatic response .
