HLSC 1F90 Lecture Notes - Lecture 17: Insulin-Like Growth Factor 1, Soy Milk, Caffeine
8 Feb 2016
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Document Summary
1/3 within a year = risk of re-fracture. Mortality: 28% of women with hip fracture die within 1 year. Genetics family history, small-boned , no physical activity, early menopause; loss of estrogen, some medications (corticosteroids, anticonvulsants), smoking, alcohol (>2 drinks/day), excessive caffeine, other nutritional inadequacies, aging. Who definition: a skeletal disorder characterized by compromised bone strength predisposing a person to an increased rick fracture. Bone strength: bone quantity (mineral bmd), bone quality (prior fracture, structure). Osteoporosis: lowers mineral content and weakens structure; increases rick of fragility fracture. Gene and protein markers of bone health. Amount of bone mineral in a given area (spine, femur). Amount of force a bone withstands before fracture, Peak bone mass: affected by genetics, physical activity, and nutrition. Can be improved by physical activity and nutrition. Attenuate bone loss of aging and loss of estrogen: physical activity, nutrition. Osteoclasts and osteoblasts need to be balanced. Bone: higher osteoblasts and activity; lower osteoclasts and activity.
