BIOL 3P51 Lecture Notes - Lecture 6: Consanguinity, Zygosity, Dwarfism

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If homo, then the entuire offspring look the same (like pxp & f1) If hetero, half will be dominant and half will be recessive: 2 gene test cross, take individual showing a recessive trait for both genes (brown body, red eyes, take an unknown (homo or hetero) individual. 29/10/2018: waardenburg syndrome type i, hearing loss, dystopia canthorum, and pigment disturbances of the iris, hair, and skin, white streak in hair, caused by mutation of pax3. Incidence ranges from 1 in 313 to 1 in 90,000 in different populations (avg. = 1 in 3,200 in us: dysfunction impacts many organs that secrete mucus, respiratory tract, pancreas, genitalia (sterile), intestine, sweat glands, clubbed fingers. If they have a ghealthy chil;d what is the probability that this child would not be a cerrir of tay-sachs disease: 100, 2/3, 1/3 of the three healthy children. Only 1 is not a carrier: x-linked inheritance, x chromosome contains many hundreds of important genes.

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