BIOL 3P50 Lecture Notes - Lecture 2: Purine, Thymine, Genetic Disorder
27 Aug 2015
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Lecture 2 - nucleic acids convey genetic information. Us microbiologist oswald t. avery identified the transforming agent as dna in. Transforming activity destroyed by deoxyribonuclease, but not ribonuclease or proteolytic enzymes. Viral genes are also nucleic acids: purification of various viruses showed that all contained nucleic acid, t2 bacteriophage experiments by hershey and chase (1952, protein coat labeled with radioactive 35s, Dna with radioactive 32p: nucleic acid but not protein was found to enter infected bacteria, dna carries genetic information while protein coat is only a protective shell. Indicated that dna was helical: high quality x-ray diffraction photographs taken by rosalind franklin in. Semiconservative replication: meselson and stahl (1958, bacteria grown in media containing heavy isotope 15n, transferred to 14n medium and monitored. In 1957, amino acids were found to be attached to transfer. Rna (trna) molecules: trna found to serve as an adaptor that can base-pair and. Read the rna template: in contrast to rna folding model.
