BIOL 3P34 Lecture Notes - Lecture 6: Gonadal Ridge, Sox9, Catenin
8 Jan 2018
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Want to find the gene behind the heart development, the once that are mutated. Each sex cell contributes half to the offspring. Mechanism for initiation of primary sex determination i mammals. A lot depends on hormone signaling and environment. The germ cells can become sperm of egg, no specification on germ cells. Theyre not determinate whether they become sperm or egg. The gonads determine it. genital ridge= undifferentiated, depends on the somatic cell. If there is interaction of wnt4 results to ovary formation. If sry is interacted, it will turn to sox9 and turn testis forming genes. The genes actively supress one another as they develop. Initially genital ridge is bipotential, can make female or male gonad and comes down to presence of y chromosome. If it"s not there, there is b catenin, results to formation of ovary. If there"s y chromosome but sox9 isnt there, cant antagonise b catenin, the organism develops into an ovary.
