BIOL 3P34 Lecture Notes - Lecture 8: Nernst Equation, Resting Potential, Loligo

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Bernstein: in the early 1900s proposed that the rmp for neurons was based selectively on the permeability of the membrane to k+ Nernst relation can be used to determine which ions contribute to the membrane potential. Compare the resting potential with equilibrium potentials of various ions. Change ion concentrations-see if membrane potential changes as predicted by the nernst equation. 10% of k+ permeability) and also to cl- Constant flied equation: is used to determine the vm of a neuron. Consider individual ion currents (for na+ and k+) Ion flux (current) depends on driving force and on membrane conductance. For sodium: ina = gna (vm ena) For potassium: ik = gk (vm ek) For a cell to be at rest, k+ and na+ currents must be equal and opposite. So there is no net flow of ions (otherwise vm would change and the cell wouldn"t be at rest) Ik = - ina gk (vm ek) =

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