BIOL 2P03 Lecture Notes - Lecture 9: Tomm22, Intermembrane Space, Hspa8
11 Feb 2016
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Tca cycle enzymes -substrate transporters -fatty acid catabolism. How are nuclear encoded proteins imported into the mitochondria. Challenge-proteins are big, the inner membrane must maintain its integrity to maintain the proton gradient. Solution-many proteins are involved in the regulated import of mitochondrial proteins while maintaining proton gradient. Figure 13. 27 3 pathways to inner mitochondrial membrane from the cytosol. Figure 13. 28 2 pathways to the mitochondrial intermembrane space. Some are always being degraded while others are being made de novo. In response to increased workload, and therefore increased atp turnover, cells make more mitochondria. As in mitochondria, the chloroplast machinery is made from proteins encoded in chloroplast dna and those encoded in nuclear dna encoded proteins include: rna polymerase, ribosomal proteins, photosystem subunits. There are many copies of genome/chloroplast and per cell. Ndna encoded proteins are made in the cytosol and imported via complexes. Same basic system of outer and inner membrane complexes.
