BIOL 2P02 Lecture Notes - Lecture 26: Peptidyl Transferase, Endoplasmic Reticulum, Ribosome-Binding Site
23 Nov 2016
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You have a big sequence of rna which is what gets transcribed processed and spliced. Rbs: is where the ribosomes are going to bind, will affect the selection of aug. Ribosome binding site is identified and both bacteria and eukaryotic cells. If you disrupt the reading frame, because of mutations or splicing error, will end up with a nonsense mutation. Nonsense mutation: type of mutation that changes reading frame or codon into stop codon. In all of the details we have to cover make a mental note to study the differences in bacteria vs. eukaryotic cells as there is exam questions based on this. Eukaryotic cells: whole bunch of little dots (ribosomes, groups of ribosomes called polysomes (polyribosome). Ribosomes are fundamental enzymatic activity for making proteins. All this is happening in cytoplasm mostly in rough endoplasmic reticulum (in eukaryotic cells) Bacteria are different, happens at the same time transcription happens review this stuff.
