BIOL 1F90 Lecture Notes - Lecture 8: Van Der Waals Force, Alpha Helix, Chemical Polarity

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9 Mar 2018

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Many cellular processes involve steps in which two or more different proteins interact with each other. Hydrophobic effects - if you have 2 alpha helices that have greasy sides, they. Ionic bonds and other polar interactions made interact, therefore you"d have all the hydrophobic ends on one side, and all the hydrophilic ends on one side. Defined regions of proteins with structural and functional differences. Fold independently of the rest of the protein. These particular amino acid sequences have been duplicated during evolution. The same domain may be found in several different proteins. When the same domain is found in different proteins, it has the same 3-d shape, chemical properties and function. Used purified (isolated) ribonuclease, and found that: Chemicals that disrupt bonds cause the enzyme to lose function. Thus, in the complete absence of any cellular factors, an unfolded protein can refold into it functional structure.

Related Questions

Is DNA a protein if so what makes up proteins, if not what it is and what are its monomers called? Describe the primary, secondary, tertiary, and quaternary structure of DNA (this sub-question is independent of the answer to the first question).

Describe electrostatic bonds, covalent bonds, van der Waals interactions, and hydrogen bonds and give an example of each.

Which of the four classes of amino acids has side chains with the greatest hydrogen-bond-forming potential?

Which has the greatest potential to form electrostatic interactions?

Which class has the greatest potential for hydrophobic interactions?

Of the following amino acids, (K), (Y), and (F), which side-chains would you expect to be the most soluble in a polar aqueous solution? Which the least?

Would you agree with the statement that many different amino acid sequences can fold into the same basic tertiary structure? What data can you cite as evidence for your position?

The type of macromolecule found in highest concentration on a weight basis in a HeLa cell is

protein.

lipid.

polysaccharide.

nucleic acid.

water

Co and Zn ions are required by humans in

microgram amounts.

gram or near gram amounts.

kilogram amounts.

d. milligram amounts.

Which description best characterizes the length of a hydrogen bond between water molecules?

About the same length as the calculated van der Waals distance for two water molecules.

About the same length as a covalent O----H bond.

Shorter than a covalent O---H bond.

Longer than a covalent O---H bond, but shorter than the calculated van der Waals distance between water molecules.

Which of the following statements about water is not true?

Water will hydrogen bond into highly ordered structures or "cages" around non-polar molecules.

The electron-rich oxygen atom of one water molecule can interact with an electron-poor hydrogen on another water molecule to form a hydrogen bond.

Water is a key player in the energetics of the hydrophobic effect.

In an ice crystal water molecules pack into open lattices consisting of five-membered oxygen rings.

At 25 degrees celsius liquid water is about 85% as hydrogen bonded as the water in ice, with each molecule in an average of 3.4 hydrogen bonds.

Which of the following is the strongest?

Ionic interactions

Permanent dipole - permanent dipole interactions

London dispersion forces

Co-linear hydrogen bonds

Which of the following is the best explanation for the hydrophobic effect?

It is caused by the attraction of hydrophobic groups for each other.

It is an entropic effect caused by the tendency of hydrophobic groups to increase their entropy by associating with other hydrophobic groups.

It is an entropic effect, caused by the tendency of water molecules to increase their entropy by excluding hydrophobic groups, which they must otherwise surround with highly ordered structures.

It is caused by the attraction of water for hydrophobic groups.

It is an entropic effect, caused by the tendency of water molecules to increase their entropy by forming highly ordered structures around the hydrophobic groups.

Which of the following is NOT defined as a buffer? (pKa PIPES-H⁺ = 6.76; pKa MOPS-H⁺ = 7.15; pKa HEPES-H⁺ = 7.47)

0.15 M MOPS, pH 6.50

0.05 M HEPES-H⁺ / 0.04 M HEPES

0.20 M PIPES, pH 7.97

0.01 M HEPES, pH 7.30

BIOL 1F90 Lecture Notes - Lecture 8: Van Der Waals Force, Alpha Helix, Chemical Polarity

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