BIOL 1F90 Lecture Notes - Lecture 3: Nadh Dehydrogenase, Pyruvate Dehydrogenase, Acetyl-Coa
23 Nov 2016
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Document Summary
Each step is catalyzed for different enzyme. Steps are seen in every living species (bacteria, archea, animal, etc) Energy investment: 2 atp hydrolyzed (requires) Rest are exergonic: phosphates from these atp are used to convert glucose to fructose-1, 6 bisphosphate over three sequential reactions. Cleavage: fructose 1, 6 bisphosphate is cleaved into 2 molecules of clyceraldehyde-3-phosphate (3 c each) Energy liberation: 2 glyceraldehyde-3-phosphate molecules are broken down into two pyruvate molecules, produces 2 nadh and 4 atp, broken down into two molecules of pyruvate which enters the. 2 nadh and 2 atp net yield. Each glucose makes 2 pyruvate which enter next step. Where negative feedback occurs: a lot of atp present, atp comes back and binds to phosphor fructokinase and inhibits production of fructose 1, 6- bisphosphate prevents further breakdown of glucose. Adp stimulates phosphofructokinase: stage 2: breakdown of pyruvate. Pyruvate dehydrogenase is enzyme that breaks down each pyruvate.
