BIOL 1F25 Lecture Notes - Lecture 5: Methyl Benzoate, Biosensor, Dopamine Transporter
18 May 2015
School
Department
Course
Professor
Document Summary
Suggested to increase release in dopamine in nac in absence of cocaine: during cocaine use, post-synaptic cells (in nac) ______(dopamine travel)_____pre-synaptic cells (in vta) Triggers euphoric effect, and use of cocaine. Associative learning: classical conditioning: brain makes association between two unrelated stimuli. Ltp can also occur at glutamate synapses in nac: i. e. strengthening of connections between hippocampus and reward pathway. Makes it vulnerable to being directly affected by cocaine use. Steps needed in understanding in l and m and drug addiction fields: understand how stimulus produces immediate effects on synapses in brain. Identify changes that occur after repeated application of stimulus: how do changes in brain cells lead to behavioural changes? a. (biggest challenge to researchers, full understanding of circuits in brain not yet possible. ^fosb induced in nac by many drugs of abuse and non-drug rewards. Experimental evidence for role of ^fosb: over-expressed ^fosb in nac in mice a.
