BIOL 1F25 Lecture Notes - Lecture 7: Substantia Nigra, Caudate Nucleus, Putamen
20 Nov 2018
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Lindvall et al. , annals of neurology 35: 172-180, 1994. Quantified pet scan results (influx constant = ki, min-1): uptake in putamen is lower on left side consistent with greater rigidity on right side of body (left side of brain controls right side of body) 2-5 months after surgery: % of time spent in off state ( ) decreased from 40-50% to ~20, # of off periods per day ( ) decreased from ~ 4 to ~ 2. Limb rigidity assessed on wrist during off state: scale: 0 = no rigidity; 3 = severe rigidity rigidity decreased on both left ( ) and right (n) sides 3-5 months after surgery. Performing 20 arm movements (pronation-supination): left ( ) and right (n) sides. Surgery: higher in off state than on state in off state , higher on right than left. 3-5 months after: time to move in off state decreased on both sides, but decreased more on right.
