BIOL 1F25 Lecture Notes - Lecture 4: Long-Term Potentiation, Mcgill University Health Centre, Retinoic Acid Receptor
13 Feb 2017
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Document Summary
Ra is the active metabolite (absorb) of vitamin a (required for memory in vertebrates) Vitamin a is important for vision, nervous system development, and normal immune response. Vitamin a deficiency can lead to night blindness, impaired development, and poor immune response: ra turns on genes (needed long term memory formation) by binding with specific receptors (rxr = retinoid x receptor, rar = retinoic acid receptor) An antagonist ,binds to receptor, does not induce biological response, blocks action of biological, operant conditioned as previously described. Antagonist= hx531 prevent ra from turning specific genes on, not water soluble dissolved in solvent (dmso) receptor antagonist impaired long term memory. Hx531 - s1-s4 decreased in pneumostome opening, 24-hour memory, dmso- s1-s4 decreased in pneumostome opening, 24-hour memory stopped water, dmso. Ec23 - s1-s2 decreased pneumostone opening, 30 no memory, dmso- s1-s2. An agonist (ec23), binds to receptor, induces biological response (can"t be dissolved in.
