PHAR2210 Lecture Notes - Lecture 22: Tinea Versicolor, Mycosis, Mucormycosis
Document Summary
Antifungal drugs: immunocompromised patients including untreated hiv/aids. Fungi are eukaryotic cells: nuclei, mitochondria, membranes. 200, 000 defined species within kingdom fungi (~1 million in total: e. g. yeasts, moulds, mushrooms, etc, many fungi are economically important, e. g. brewer"s yeast or penicillium mould. Fungi are present in the environment or may coexist with humans (commensals) In people with poor immune function, dormant fungal infections can trigger disease (i. e. opportunistic: often can be chronic in nature, workers exposed to soil, dust, etc are often. Aspergillosis a range of nasal, respiratory, dermal & disseminated diseases in the immunocompromised that range from mild to life-threatening vulnerable (e. g. farmers, gardeners, etc: a group of mucormycetes moulds can cause. Some key differences between fungi & other cells: Unlike mammalian cells, fungal cell membranes contain ergosterol, not cholesterol common antifungal drugs take advantage of these distinctive features. Yeasts: also called sprouting-fungi , oval-shaped cells which contain granules and frequently vacuoles, grow by forming buds.
