MICR2209 Lecture Notes - Lecture 7: Immunopathology, Mast Cell, Atopy
7 Feb 2019
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2nd row- complement is a pathway, many pathways = complex and each step can have problems. 3rd row lympho = all lymphocytes , lead to bc tumours, driven by ebv increased susceptibility to bacterial infections are assc with phagocytes and complement deficiencies. Those who get ebv are susceptible to x-linked lympho-proliferative syndrome. If defect = no class switch, cells don"t proliferate, no gc, hyper igm. Hiv infects cd4+ t cells causes destruction of ir, recall cd4+ t cells are helper cells. Aging older people have less repertoire and react slower to new ag. Immunosuppressive drugs suppressing latent problems that may recur in future. Hiv virus conc in blood will inc (not shown) Syndrome = patient dies from complications of infections. Ir directs against self ag (instead of self mhc) *don"t need to know why self ag activates ir. T cells react to epitopes of mbs in cns, destructing myelin of white matter.
