IMED3004 Lecture Notes - Lecture 12: Cerebral Edema, Gonadotropic Cell, Hypoglycemia
1 Nov 2020
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Pituitary gland: integrates +/- signals to keep hormone levels normal. Anterior lobe (alp): corticotrophs acth lactotrophs prolactin (prl) somatotrophs (50%) gh thyrotrophs tsh gonadotrophs fsh/lh. Hypothalamopituitary-adrenal (hpa) axis regulates synthesis & secretion of adrenal corticosteroids. Circadian/diurnal rhythm: mineralocorticoids, aldosterone - main mc. Side chain cleavage (scc) rate limiting step in steroid synthesis. Cortex zones - reflect expression of specific steroidogenic enzymes needed to make mc, gcs & sex hormones. Angiotensin ii (mc) positively regulate cholesterol conversion to pregnenolone ( scc activity) Aminoglutethimide scc to stop production of all steroids. Cho metabolism protein catabolism adipose tissue distribution: anti-inflammatory/immunosuppressive effects. Resistance to stress : mineralocorticoids, water & electrolyte homeostasis, na+ retention. Both of these are important for the stress response. Lipophilic molecule crosses pm & binds cytoplasmic receptor (gr) Dimeric gr binds gres to alter transcription of target genes. Transcriptional tethering" tether partner tfs to dna, e. g. nf- b.
