IMED1003 Lecture Notes - Lecture 12: Glycogen Phosphorylase, Riboflavin, Acetyl Group
17 Sep 2018
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Document Summary
Tca cycle: know the processes of glucose metabolism. Glycolysis occurs in the cytosol: glucose is broken down to pyruvate (3 carbon sugar- one is lost as co2, and the other 2 is lost, 2atp and 2 nadh, 10 steps (3 main players for regulation) The next 2 steps of respiration in mitochondrion: pyruvate oxidation, tca cycle. Conversion of pyruvate to acetyl coa is not part of the tca cycle. Tca cycle begins when the acetyl coa binds to the citrate: understand the reaction catalysed by pdh and its regulation. Pivotal molecule in metabolism: all of out molecuels feed into this. As we push out carbon dioxide, we are harnessing energy in the form of electrons. Get gtp- same energy wise as atp interconvert them. The oxidation (oxidative decarboxylation) of: pyruvate to acetyl coa- is the irreversible route from. Glycolysis to tca cycle (mitochondria)- forward driven reaction: oxidation- end up with carbon dioxide.
