ANHB3323 Lecture Notes - Lecture 10: Follicular Dendritic Cells, Endoplasmic Reticulum, Dendritic Cell
3 Jun 2018
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LECTURE TEN: Immunobiology
Inflammation:
• Also called inflammatory response
• Localized response
• Triggered by stimulus that kills cells/injures tissues
• Characterized by
o Swelling (tumor)
o Redness (rubor)
o Heat (calor)
o Pain (dolor)
Immune Surveillance:
• Throughout the body
• Some organs have developed strategies towards the immune system to
keep it our or put it under control
• Immune privileged organs
o Brain
o Eye
o Testis
o Thyroid gland
• Immune system is present in these organs but under extreme control
because
• Immune response may actually damage structures in those organs → loss
of function
• Humoral immunity → soluble factors like complement,
cytokines/chemokines, antibodies
• Cellular immunity → immune cells
• Innate immunity → reacts immediately
• Adoptive immunity → adaptive, longer lasting, more controlled
Function of Immune Cells:
• Innate immunity cells
o Include
▪ Granulocytes
▪ Macrophages
▪ Mast cells
▪ Natural killer cells
o Bone marrow derived
o Mature in bone marrow
o Released into and function throughout body
o Recruited to other parts
• Intermediate cells
o M-cells
▪ Epithelial (gut, respiratory tract)
▪ Take antigens from gut, present to resident immune cells
▪ Transport antigens from lumen to lamina propria
▪ Antigens not normally allowed to cross lining
find more resources at oneclass.com
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o Dendritic cells
▪ Monocytic (subpopulation of macrophages)
▪ Take up antigens from environment
▪ Process antigens in lysosomal compartment
▪ Activate phagocytic cells
▪ Present antigens on MHC surface molecules to T
lymphocytes
o Follicular dendritic cells
▪ Stromal cell derived
▪ Located in areas with B cells
▪ Process antigens to B cells
• Adoptive immunity cells
o T-lymphocytes
▪ CD4 or CD8
▪ Helper
▪ Suppressor
▪ Memory
o B-lymphocytes
▪ Plasma cells
▪ Produce antibodies
Neutrophil Granulocytes and Macrophages:
• Take up foreign particles
o Bacteria
o Viruses
o Dead cells
• Destroy them in lysosomes with no antigenicity
• Neutrophils
o Not resident in tissues
o Survive up to 24 hours
o Very mobile
o Die after phagocytosis
• Macrophages
o Long lasting phagocytes
o Can engulf large numbers of pathogens
o Survive up to a few months
o Act as antigen presenting cells to T cells
Other Innate Immune Cells:
• Deliver substances from storage granules
• Kill parasites/tumor cells
• Induce or support inflammatory response
• Eosinophil
o 1-6% of white blood cells
o Contribute to initiation of immune response, combating parasites,
viral infections, allergies, asthma
• Basophil
o 0.01-0.3% of white blood cells
o Release heparin and histamine
find more resources at oneclass.com
find more resources at oneclass.com
Document Summary
Inflammation: also called inflammatory response, localized response, triggered by stimulus that kills cells/injures tissues, characterized by, swelling (tumor, redness (rubor, heat (calor, pain (dolor) Immune surveillance: throughout the body, some organs have developed strategies towards the immune system to keep it our or put it under control. Immune privileged organs: brain, eye, testis, thyroid gland. Immune system is present in these organs but under extreme control because. Immune response may actually damage structures in those organs loss of function: humoral immunity soluble factors like complement, cytokines/chemokines, antibodies, cellular immunity immune cells, adoptive immunity adaptive, longer lasting, more controlled. Innate immunity cells: include, granulocytes, macrophages, mast cells, natural killer cells, bone marrow derived, mature in bone marrow, released into and function throughout body, recruited to other parts. Other innate immune cells: deliver substances from storage granules, kill parasites/tumor cells, eosinophil. Immunological surveillance carried out by nk cells.
