ANHB3323 Lecture Notes - Lecture 20: Durotaxis, Biomimetics, Bone

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3 Jun 2018

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LECTURE TWENTY: ECM Biomimicry

Biomimicry:

• Re-creation/generation/production of a highly complicated natural ECM

in vitro

• Mimicking diseased ECM to study cell responses

• Components → stiffness/fiber/protein presentation

Mimicking ECM Properties - Stiffness:

• Range of stiffness found each individual tissue

• Fat/brain → softest

• Muscle/cartilage → middle

• Cortical bone → stiffest

• Step vs. linear gradient

Microcontact Printing:

• To control shape

• Works like a stamp

• Contains serum → collagen and fibronectin

• Cell grabs these proteins and adheres to it

• Zemraxis → repetitive step gradient hydrogel → used as a platform

• Cells move to stiffer end → durotaxis

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