300905 Lecture Notes - Lecture 47: Pyoderma Gangrenosum, Deep Vein Thrombosis, Erythema Nodosum

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As uc is believed to have a systemic origin, people with uc may present with comorbidities leading to symptoms and complications outside the colon. The frequency of such extraintestinal manifestations has been reported as between 6 and 47%, and include: aphthous ulcer of the mouth, ophthalmic. A genetic component to the cause of uc can be hypothesized based on: aggregation of ulcerative colitis in families. Identical twin concordance rate of 10% and dizygotic twin concordance rate of 3: ethnic differences in the number of cases, genetic markers and linkages. Twelve regions of the genome may be linked to uc, including, in the order of their discovery, chromosomes 16, 12, 6, 14, 5, 19, 1, and 3, but none of these loci has been consistently shown to be at fault, suggesting that the disorder is influenced by multiple genes. For example, chromosome band 1p36 is one such region thought to be linked to inflammatory bowel disease.

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