CAM202 Lecture Notes - Lecture 11: Schistosomiasis, Melanoma, Dyslipidemia
Document Summary
Sinusoidal lining cells consist of specialised fenestrated endothelial cells and specialized macrophages or kupffer cells. In the smaller portal tracts the ductules join the interlobular bile ducts and continues to drain into larger bile ducts until it exits the liver at common hepatic duct. Sexual spread much less common than hep b. Syndromes of viral hepatitis: acute subclinical/anicteric, most recover, unaware of being infected, eg. for hep c only aware of viral infection when cirrhosis appears, hardly any clinical symptoms, acute symptomatic/icteric recovery. Histology of acute hepatitis: predominantly lobular inflammation, within hepatcyte cords. Lobular regeneration and disarray: ballooning hepatocyte degeneration, apoptotic bodies (acidophils, mononuclear inflammatory cells, with occasional eosinophils and neutrophils, canalicular cholestasis, hepatocyte dropout, necrosis. Focal confluent and bridging necrosis (fulminant hepatitis) interface. Inflammation within lobules of liver: very hard to make out the individual single cords, hepatocytes appear disorganized, acidophil body (red circle, basically a dead hepatocyte, bridging necrosis (highlights, residual hepatocyte.