PCOL2605 Lecture Notes - Lecture 16: Diastolic Heart Failure, Valvular Heart Disease, Coronary Artery Disease

• School: University of Sydney
• Department: Pharmacology
• Course: PCOL2605
• Professor: Brooke Storey Lewis

Document Summary

4/9/18 (cid:862)the(cid:396)e is a(cid:374) i(cid:374)a(cid:271)ilit(cid:455) of the hea(cid:396)t to pu(cid:373)p suffi(cid:272)ie(cid:374)t (cid:271)lood to (cid:373)eet the (cid:373)eta(cid:271)oli(cid:272) (cid:374)eeds of the tissues, i(cid:374) the p(cid:396)ese(cid:374)(cid:272)e of a(cid:374) ade(cid:395)uate filli(cid:374)g p(cid:396)essu(cid:396)e(cid:863) Myocardial infarction: (cid:455)stoli(cid:272) hea(cid:396)t failu(cid:396)e (cid:894)hea(cid:396)t failu(cid:396)e (cid:449)ith (cid:396)edu(cid:272)ed s(cid:455)stoli(cid:272) fu(cid:374)(cid:272)tio(cid:374)(cid:895): Impaired pumping ability of the ventricle leading to a reduced cardiac output (systolic function) Left ventricle ejection fraction is less than 40% (normal is around 50%) Echocardiography (ultrasounds: diastoli(cid:272) hea(cid:396)t failu(cid:396)e (cid:894)hea(cid:396)t failu(cid:396)e (cid:449)ith p(cid:396)ese(cid:396)(cid:448)ed s(cid:455)stoli(cid:272) fu(cid:374)(cid:272)tio(cid:374)(cid:895) Tiff, (cid:272)a(cid:374)"t ope(cid:374) as (cid:373)u(cid:272)h, (cid:272)a(cid:396)dia(cid:272) output is down. Does(cid:374)"t (cid:396)ela(cid:454) p(cid:396)ope(cid:396)l(cid:455) so it does(cid:374)"t fill p(cid:396)ope(cid:396)l(cid:455) 30-50% of patients with heart failure (often elderly females) are thought to have diastolic heart failure (heart failure with preserved systolic function) Ventricle becomes thick with stiffened walls and a small cavity. Ejection fraction is normal but cardiac output is reduced. Heart failure: whe(cid:374) the hea(cid:396)t (cid:271)egi(cid:374)s to fail, (cid:373)a(cid:374)(cid:455) s(cid:455)ste(cid:373)s a(cid:396)e (cid:271)(cid:396)ought i(cid:374)to pla(cid:455) i(cid:374) a(cid:374) attempt to maintain cardiac output.