PHAR3817 Lecture Notes - Lecture 15: Regulation Of Gene Expression, Dna Virus, Carboxylic Acid
22 Jul 2018
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Document Summary
Design of antiviral drugs: herpes virus (herpes simplex virus (hsv-1 and 2); herpes-zoster (shingles); chickenpox) Dna-containing viruses use the central dogma dna goes to rna goes to protein. In rna-containing viruses, the information flow is reversed, thus, rna goes to dna using the enzyme reverse transcriptase: attachment, penetration, uncoating, replication, assembly, release. Pgp 41, 121 bind receptor on cell to penetrate via endocytosis in order to uncoat message to formulate another virus. rdna embeds into the nucleus to start cycle of replication. We need to inhibit the 6 steps listed such as inhibiting the receptor or vaccine used to bind to virus to stop binding, etc. (step 1) Inhibition or interference of viral attachment to host cell. Interference with release of virus from cell surface membrane. Virus usually changed the cell"s dna, which moves on to rna to make proteins. Hiv is a virus da changed rna which goes back to dna to move forward to proteins.
