PHAR3817 Lecture Notes - Lecture 3: Adrenergic Receptor, International Union Of Basic And Clinical Pharmacology, Sympathetic Nervous System
22 Jul 2018
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Document Summary
Autonomic nervous system (ans) = involuntary control over the contraction of smooth muscle, cardiac muscle and glandular activity. Cholinergics - mediate their effect via receptors stimulated by acetylcholine (ach) Adrenergic - medicate their effect via receptors stimulated by epinephrine/norepinephrine (adrenaline/noradrenaline) Tyrosine is transferred via protein into the membrane where it is transformed into noradrenaline. The action potential along adrenergic nerve to the terminal shows a vesicle fusing and release noradrenaline into the synaptic cleft and diffuses. There is a reuptake mechanism when there is too much noradrenaline by reuptake transporters. Noradrenaline when outside is also prone to degradation by mao in neurons (mitochondria) and comt, which breaks down noradrenaline (metabolized) Alpha ( ) & beta ( ) adrenergic receptors: nor-adrenaline ( > ) preference, adrenaline ( = ) Iuphar: 1 (a, a, b, b & d, d), 2 (a,b & c), 1, 2, 3. Blood vessels ( 1 > 2: predominately constricts.
