PHAR3817 Lecture Notes - Lecture 13: Dry-Powder Inhaler, Spray Drying, Aerosol
22 Jul 2018
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Document Summary
Development of inhaled mannitol as a respiratory product. 4. 5% saline as an osmotic challenge to the airways. Exercised induce asthma: hypertonic saline use as osmotic challenge to airway. Disadvantage: electricity, big bulky, preparation of solution daily, tedious. To use a dry powder preparation of an osmotic substance to provoke airway narrowing in people with active asthma or rhinitis: can be anything that dissolve water that creates hypertonic solution and non toxic bacteria. Such a preparation would provide a simple and inexpensive test that could be used at the point of care" and replace the need for sophisticated equipment in hospital-based laboratories. Hospital setting testing thus not all can access this. Need to find a suitable method to measure lung function. Powder processing (kg in order to be sustainable consider yield production) Filling & packaging (how well can you deliver?) Basic criteria for a successful inhalation product: bioavailable clinical response, deliverable, aerosol performance, production rate.
