PHAR2822 Lecture Notes - Lecture 2: Sufentanil, Migraine, Tramadol
Document Summary
Paed: not in pharmacy (specialist only) Adult: 75 150mg d in 2 or 3 doses (cid:523) (cid:858)(cid:856)(cid:856)mg d(cid:524) (cid:498)diclofenac (cid:857)(cid:861)(cid:856) mg/day is the most effective nsa)d available at present(cid:499) (cid:523)costa (cid:858)(cid:856)(cid:857)(cid:862), Theoretically reduced gi adrs reduced cox-i inhibition adrs still present. Indications: pain associated with inflammation, pyrexia good in combination with regular paracetamol. Precautions: cv risk, angina, vascular surgery, asthma, coagulopathies, dehydration, gi (esp bleeding), renal, Adrs: nvd, gi bleed, liver enzymes, ht, electrolyte, renal. Breastfeeding: non-selective, appear safe, selective: less data, appear safe. Link with miscarriage (?esp time of conception) Do not use in late pregnancy: ductus arteriosus closure, fetal renal impairment, decrease in volume of amniotic fluid, inhibition of platelet aggregation, and may delay labour and birth. Mimic endogenous opioids bind -opioid rs in cns reduce transmission of pain impulse by acting pre- and post-synaptically in spinal cord. Tolerance: rapid and lasting, require increasing dose regimens receptor modulation.
