MEDI211 Lecture Notes - Lecture 4: G Protein–Coupled Receptor, Glycogen Synthase, Glycogen Phosphorylase
6 Aug 2018
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G-6-p glycolysis: gpb is inactive; gpa is active and breaks down glycogen linkages, the pathway activates glycogen phosphorylase and inhibits glycogen synthase enzyme (cannot create glycogen) G-6-p glycolysis: pathway inhibits glycogen synthase enzyme (cannot create glycogen) Liberation of triglycerides from adipocytes: hormone sensitive lipase: a major determinant of circulating [fa, hsl controls breakdown of fat stores for energy, hydrolyses triglycerides fatty acid + glycerol = lipolysis, ffas diffuse out of adipocytes into bloodstream. In blood: fa transported in the blood bound to carrier protein (e. g. albumin: transported to site of demand, activated in response to, decreased insulin insulin inhibits hsl. Increased epinephrine e. g. sympathetic nervous system: other e. g. increased growth hormone. Glucagon-induced glucose synthesis by the liver: glucagon binds to glucagon receptor on hepatocyte, activates adenylyl cylase/camp/protein kinase (pk) pathway (conversion of pka to. Inhibits glucokinase (conversion of glucose to glucose-6-phosphate) (1)
