HUBS1403 Lecture Notes - Lecture 13: Electron Transport Chain, Cellular Respiration, Inner Membrane

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Lecture'13'–'Cellular'Metabolism'1'
!
1. Recall!what!metabolism,!catabolism!and!anabolism!are.!
Metabolism!refers!to!all!the!chemical!reactions!that!occur!in!the!body!
Catabolism!is!those!chemical!reactions!that!break!down!complex!molecules!into!simpler!ones!
Anabolism!is!those!chemical!reactions,!which!synthesise!smaller!molecules!to!create!more!complex!
ones.!
!
2. Anabolism!consumes!ATP!and!catabolism!exerts!ATP.!ATP!from!catabolism!is!used!to!fuel!anabolism.!
!
3. Glycogenesis!is!the!process!of!turning!glucose!into!glycogen!for!storage.!It!is!anabolic.!
!
4. Glycogenolysis!is!the!process!of!turning!glycogen!into!glucose!so!it!can!be!used.!It!is!catabolic.!
!
5. The!body!uses!many!things!for!energy!if!needed.!What!is!the!primary!source!of!energy!and!why?!
Carbohydrates,!protein!and!fat!
!
6. If!a!substance!is!oxidised!it!loses!electrons!and!energy.!If!a!substance!is!reduced!it!gains!electrons!and!
energy.!NAD+!is!reduced!to!NADH!in!glycolysis.!
!
7. In!K2+!!!K4+!is!the!ion!oxidised!or!reduced?!How!many!electrons!are!gained/lost?!
2!electrons!are!lost!
!
8. Glycolysis!
What?!
A!set!of!reactions!in!which!one!glucose!molecule!is!oxidised!and!two!
molecules!of!pyruvic!acid!are!produced.!!
Where?!
Cytoplasm!and!mitochondria!
Aerobic/Anaerobic?!
Both!!
Net!gain!of!ATP!molecules!
for!every!glucose!molecule?!
2!molecules!of!ATP!for!every!one!glucose!molecule!
Formula!
C6H12O6!+!2NAD+!+!2ADP!+!2P!!!2CH3(C=O)COOH!+!2ATP!+!2NADH!+!2H+!
When!there!is!sufficient!
oxygen,!what!is!formed?!
Pyruvic!acid!
When!there!is!insufficient!
oxygen,!what!is!formed?!
Lactic!acid!
!
9. Krebs!Cycle!
Other!names!used?!
Citric!acid!cycle,!tricarboxylic!acid!cycle!
What?!
These!reactions!oxidise!acetyl!coenzyme!A!and!produce!CO2,!ATP,!
NADH!+!H+!and!FADH2.!
Where?!
Mitochondria!!
Aerobic/anaerobic?!
Aerobic!!
In!one!cycle,!how!many!of!each!
molecule!(ATP,!NADH!and!FADH2)!
are!produced?!
3!NADH!
1!FADH2!
1!ATP!
!
10. Electron!Transport!Chain!
What?!
These!reactions!oxidise!NADH!+!H+!and!FADH2!and!transfer!their!
electrons!through!a!series!of!electron!carriers.!
Where?!
Inner!membrane!of!mitochondria!
Aerobic/anaerobic?!
Aerobic!!
What!do!NADH!and!FADH2!do?!
They!are!affixed!with!electrons!and!are!transferred!into!the!inner!
membrane!of!the!mitochondria.!They!release!their!electrons!
during!their!travel!down!the!electron!transport!chain.!
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