PHRM3041 Lecture Notes - Lecture 5: Colloid, Cyclotron, Cyclophosphamide
Document Summary
Isotopes of an element have the same number of protons but different numbers of neutrons in the nuleus. Isotopes will attempt to be in the most stable form. Rearrangements within the nucleus result in radioactivity. Imaging scans: non imaging platelet, red cell survival assessment. Examples of radiopharmaceuticals: technetium-99m-based (shown to right) Readily available from a generator (widely available) Chemically versatile: others, those used for positron emission tomography. Very useful to image cellular and molecular events (underlying biochemistry: proliferation, oxygen metabolism, tumour receptor density, bone remodelling. Radiopharmaceuticals for pet usually requires close access to a cyclotron: accelerates charged particles for a collision with a target which creates a radioactive isotope which is added to another molecule, 15o, 13n, 11c and 18f. Tumour marker based of increased glucose transport in tumours: 3"-deoxy-3"-[18f]fluorothymidine (flt) Allows visualization of cells undergoing dna replication: 18f- Allows visualization of bone reaction to tumours. Newer techniques pet with mri, amino acid tracers for pet (11c-alpha-methyl-i-tryptophan [amt])
