PHRM3031 Lecture Notes - Lecture 1: Clinical Trial, Graph Theory, Paracetamol

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10 Aug 2018
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An important component of defining best evidence for a particular question. Non-randomised controlled or follow-up study with sufficient numbers. Rcts, nested case-control studies, n-of-1 studies or observational study with large effect. Rare systematic review of rcts or n-of-1 study. Individual rcts or (exceptionally) an observational study with dramatic effect. This table is a summary of oxford centre for evidence-based medicine"s levels of evidence for assessing drug benefits and harms. At its most simple, critical appraisal is a matter of reading the study and assessing the degree to which: 1 you believe the results, and, 2 you can apply the results in your practice. Lecture 2 casual questions, bias and study designs. We all have an intuitive sense of what we mean by cause, but: there has been a reluctance in epidemiology to talk explicitly about causes; and, It is surprisingly hard to pin down an account of what it means to say that a is a cause of b.

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