MICR3002 Lecture Notes - Lecture 5: Molecular Motor, Dynein, Kinesin

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28 Aug 2018
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Compartmentalisation in eukaryotic cells results in accumulation of virion components separated into different organelles: thus, manipulation of host intracellular trafficking of viral nucleic acids, proteins and glycoproteins is vital. Delivery to correct address : example: enveloped viruses need their nucleic acids and proteins directed to membranes, so that viral glycoproteins can be embedded. Some viruses need morphogenic factors: these are not viral structural proteins, but are required to aid in assembly, also known as molecular chaperones. Some viruses self-assemble: example: a mixture of tmv proteins and rna will automatically assemble into an infectious particle inside a test tube, due to its structure being at a minimum free energy state. Shell proteins bundle to form intermediate base units of structure. Bonds are formed between these structural units and the protein shell will assemble. Selective packaging of the viral genome and other essential components occurs, via signalling for recognition. Some viruses will then acquire an envelope from the host cell (not all)

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